I know vPC back to back to avoid spanning tree between two pairs of Nexus.
But I've two 4500 pairs and I need to connect them. Is there a way to do something similar to the vPC back to back to don't use spanning tree?
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You can configure VSS on Cisco 4500E, The Cisco Virtual Switching System is a clustering technology that pools two Cisco Catalyst 4500-E Series Switches with Cisco Catalyst Supervisor Engine 7-E or 7-LE or two Catalyst 4500-X Series Switches into a single virtual switch. In a VSS, the data plane of both clustered switches is active at the same time in both chassis. VSS members are connected by virtual switch links (VSLs) using standard Gigabit or 10 Gigabit Ethernet connections between the VSS members. VSLs can carry regular user traffic in addition to the control plane communication between the VSS members. you could find more info on the below link: Virtual switching system (VSS) Configuration For Cisco 4500 series switches